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Journal of Pharmacology And Experimental Therapeutics, Vol. 135, Issue 1, 34-38, 1962
Copyright © 1962 by American Society for Pharmacology and Experimental Therapeutics

THE SENSITIVITY OF THE ISOLATED RABBIT ILEUM TO SYMPATHOMIMETIC AMINES FOLLOWING RESERPINE PRETREATMENT

W. W. Fleming 1 and J. L. Schmidt 1

1 Departnuent of Pharmacology, West Virginia University Medical Center, Morgantown, West Virginia

The effect of chronic reserpine treatnmemmt on time sensitivity of the isolateol rabbit ileum to sympathomimetic agents has been investigated. Reserpine was found to increase the sensitivity of the ileum to the following catecholamines: epinephrine, norepinephrine and isoproterenol. The sensitivity to ephedrine was unchanged, while the sensitivity to tyramine was greatly reduced.

These results are discussed in relation to the mechanism of action of ephedrine anmd tyramine and in relation to time sensitivity of other organs to various sympathomimetics following denervation and reserpine pretreatment.

Submitted on June 12, 1961






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