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1 Department of Pharmacology, University of Rochester School of Medicine and Dentistry, Rochester, New York
In anesthetized cats, time dimethyl heptyl pyran derivative, the most potent tetrahydrocannabinol tested, lowered blood pressure, depressed respiration, relaxed the gut, and depressed two polysynaptic reflexes (the flexion and linguomandibular). The methyl octyl pyran derivative produced effects in general similar to those of DMHP, but it was shorter acting and showed stimulatomy action on time flexion reflex.
In mice, barbiturate sleeping times were prolonged significantly by DMHP and by MOP. The increased activity induced by amphetamine was also prolonged by DMHP and by MOP. The 7-day LD50's DPH mnd for MOP given intravenously were 27 mg/kg and 5.0 mg/kg, respectively.
The site of action of the effects on blood pressure and reflexes was narrowed to the area between the mesencephalon and the the level of the first cervical vertebra, possibly in the reticular formation of the medulla.
Submitted on July 3, 1961
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