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Journal of Pharmacology And Experimental Therapeutics, Vol. 135, Issue 1, 21-24, 1962
Copyright © 1962 by American Society for Pharmacology and Experimental Therapeutics

CENTRAL INHIBITION OF VASOMOTOR ACTIVITY BY GUANETHIDINE

Yoshihiro Kaneko 1, James W. McCubbin 1, and Irvine H. Page 1

1 Research Division, The Cleveland Clinic Foundation, Cleveland, Ohio

Guanethidine given intravenously to dogs did not inhibit central vasomotor activity or centrally mediated cardiovascular reflexes as reflected by efferent sympathetic activity in the splanchnic nerve.

Small dosage of guanethidine injected into a lateral ventricle or into the cisterna magna caused hypotension, bradycardia, marked inhibition of response to carotid occlusion, decrease of splanchnic nerve activity and disappearance of reflex changes in nerve activity following carotid occlusion or injection of a pressor drug. It is suggested that this action of guanethidine may contribute to its hypotensive effect when given chronically since, with time, small amounts may penetrate the blood-brain barrier.

Submitted on June 12, 1961






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