JPET Introducing ALZET?ew Model 2006 Pump

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Journal of Pharmacology And Experimental Therapeutics, Vol. 135, Issue 1, 120-127, 1962
Copyright © 1962 by American Society for Pharmacology and Experimental Therapeutics

PHYSICOCHEMICAL PROPERTIES OF DRUGS THAT CONTROL ABSORPTION RATE AFTER SUBCUTANEOUS IMPLANTATION

Berton E. Ballard 1 and Eino Nelson 1

1 School of Pharmacy, University of California Medical Center, San Francisco, California

An absorption rate hypothesis is presented to relate absorption rate of implanted solid drugs to the various physical and chemical properties of the drugs and fluids at the site. Equations were developed to account for the absorption of certain organic weak acids, weak bases, and neutral compounds and tested for validity with experimental results found by implantation into rats of a number of substances in these classes. Experimentally observed and theoretically calculated absorption rates were in reasonable agreement.

Submitted on June 26, 1961






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Copyright © 1962 by the American Society for Pharmacology and Experimental Therapeutics.