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Journal of Pharmacology And Experimental Therapeutics, Vol. 134, Issue 3, 341-346, 1961
Copyright © 1961 by American Society for Pharmacology and Experimental Therapeutics

THE BLOOD PRESSURE EFFECTS OF 3-AMINOPROPYL-N'-METHYL ISOTHIURONIUM BROMIDE HYDROBROMIDE IN THE CAT

Victor DiStefano 1, Phyllis S. Korn 1, and Daniel E. Leary 1

1 The Department of Pharmacology, University of Rochester, School of Medicine and Dentistey, Rochester, New York

APMT produced a moderate hypertension of unusual duration unrelated to a release of epinephrine from the adrenal medulla or a stimulation of sympathetic receptors. Doses of more than 4 mg/kg of APMT gave rise to a transient hypotension preceding the hypertensive response.

Increases in spleen volunue followed administration of APMT.

Biphasic changes in limb volumue and blood flow were correlated with blood pressure changes. The APMT hypertension is attributed to a direct constrictor action on vessels in the skeletal musculature. A fleeting vasodilation is postulated to account for the transient decrease in blood pressure following large doses of APMT.

Submitted on May 25, 1961






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Copyright © 1961 by the American Society for Pharmacology and Experimental Therapeutics.