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Journal of Pharmacology And Experimental Therapeutics, Vol. 134, Issue 3, 332-340, 1961
Copyright © 1961 by American Society for Pharmacology and Experimental Therapeutics

THE PHARMACOLOGY OF PRODILIDINE HYDROCHLORIDE, A NEW ANALGETIC AGENT

John W. Kissel 1, James R. Albert 1, and Gale C. Boxill 2

1 Department of Pharmacology, Research Center, Mead Johnson & Company, Evansville, Indiana
2 Department of Pharmacology, Warner-Lambert Research Institute, Morris Plains, New Jersey

The analgetic activity of prodilidine hydrochloride (1,2-dimethyl-3-phenyl-3-pyrrolidyl propionate hydrochloride) was demonstrated in the rat, mouse and dog in tests using noxious thermal, mechanical, chemical, and electrical stimuli. Analgetic potency was generally equivalent to that of codeine sulfate.

Prodilidine HCl was unable to suppress withdrawal phenomena in morphine-dependent monkeys.

Prodilidine HCl had no respiratory depressant, antipyretic, hypothermic, or antitussive activity at analgetic levels. However, it did produce an early potentiation and late reduction of pentobarbital anesthesia in mice. The crossed extensor reflex was augmented in the spinal cat. Cardiovascular and gastrointestinal studies indicated no deleterious effects at therapeutic levels.

Submitted on May 12, 1961






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Copyright © 1961 by the American Society for Pharmacology and Experimental Therapeutics.