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Journal of Pharmacology And Experimental Therapeutics, Vol. 134, Issue 3, 325-328, 1961
Copyright © 1961 by American Society for Pharmacology and Experimental Therapeutics

INHIBITION OF H3-NOREPINEPHRINE RELEASE BY MONOAMINE OXIDASE INHIBITORS

Julius Axelrod 1, Georg Hertting 1, and Raymond W. Patrick 1

1 Laboratory of Clinical Science, National Institute of Mental Health, National institutes of Health, Bethesda, Maryland

After the intravenous administration of H3-norepinephrine, it was taken up by the heart and slowly released over a period of days. Long-acting monoamine oxidase inhibitors blocked the slow release of H3-norepinephrine. Long-acting and short-acting monoamine oxidase inhibitors blocked the releasing action of reserpine on H3-norepinephrine in the heart. On the basis of these observations it is proposed that monoamine oxidase inhibitors elevated the catecholamine concentration in certain tissues by blocking the release of the hormone from its binding site.

Submitted on May 11, 1961




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Copyright © 1961 by the American Society for Pharmacology and Experimental Therapeutics.