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Journal of Pharmacology And Experimental Therapeutics, Vol. 134, Issue 1, 117-122, 1961
Copyright © 1961 by American Society for Pharmacology and Experimental Therapeutics

EVALUATION OF BORON COMPOUNDS FOR USE IN NEUTRON CAPTURE THERAPY OF BRAIN TUMORS. I. ANIMAL INVESTIGATIONS

A. H. Soloway 1, R. L. Wright 1, and J. R. Messer 1

1 Neurosurgical Service, Massachusetts General Hospital, and the Department of Surgery, Harvard Medical School, Boston, Massachusetts

Ten organic boron compounds and boric acid have been evaluated in mice for toxicity. Tumor: brain boron ratios have been studied in animals with subcutaneous transplanted gliomas.

Two of the more promising compounds, 3-amino-4-carboxybenzeneboronic acid and m-boronosuccinanilic acid have been studied in cats by both intravenous and intracarotid injection. Tissue concentrations have been determined.

Submitted on March 10, 1961




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Copyright © 1961 by the American Society for Pharmacology and Experimental Therapeutics.