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Journal of Pharmacology And Experimental Therapeutics, Vol. 133, Issue 3, 357-363, 1961
Copyright © 1961 by American Society for Pharmacology and Experimental Therapeutics

A COMPARISON OF THE ANTICONVULSANT ACTIVITY OF MEPIVACAINE AND LIDOCAINE

Charles A. Berry 1, John H. Sanner 1, and H. H. Keasling 2

1 Department of Pharmacology, College of Medicine, State University of Iowa, Iowa City, Iowa
2 Pharmacology Research, The Upjohn Co., Kalamazoo, Michigan

Mepivacaine and lidocaine have been demonstrated to be effective anticonvulsants in the standard mouse screening tests, possessing activity similar to that of diphenylhydantoin but much shorter in duration of action. These materials are also effective in blocking electrically induced cortical afterdischarge in the unanesthetized rabbit. This latter method has been investigated as a possible screening procedure and technique of bioassay of anticonvulsant materials. However, it does not appear that use of suppression of cortical afterdischarge yields any information about these drugs not obtained by anticonvulsant screening methods currently in use.

Submitted on March 6, 1961






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