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Journal of Pharmacology And Experimental Therapeutics, Vol. 133, Issue 3, 332-334, 1961
Copyright © 1961 by American Society for Pharmacology and Experimental Therapeutics

THE ABSENCE OF BLOOD-BRAIN BARRIER FROM CERTAIN AREAS OF THE CENTRAL NERVOUS SYSTEM

Cedric W. M. Wilson 1 and Bernard B. Brodie 2

1 Department of Pharmacology and General Therapeutics, University of Liverpool, England
2 Laboratory of Chemical Pharmacology, National Heart Institute, National Institutes of Health, Bethesda, Maryland

N-acetyl-4-aminoantipyrine and sulfaguanidine slowly penetrate the cerebrospinal fluid and the brain proper, but enter the water space of the adenohypophysis, the neurohypophysis, the area postrema and the intercolumnar tubercle almost as readily as they penetrate the water space of liver and muscle. These results indicate that the blood-brain barrier does not exist in these brain regions.

Submitted on March 3, 1961






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Copyright © 1961 by the American Society for Pharmacology and Experimental Therapeutics.