EFFECTS OF NERVE STIMULATION AND DRUGS ON THE EXTRAPULMONARY PORTION OF THE PULMONARY VEIN

¹ Rothschild Hadassah University Hospital and Hebrew University, Hadassah Medical School, Jerusalem
² Department of Pharmacology, University of Pennsylvania Schools of Medicine, Philadelphia, Pennsylvania

Pressure-flow relationships of the extrapulmonary portion of the pulmonary vein in the intact and denervated lung of anesthetized dogs were determined. A rise in pressure and a fall in resistance were observed with increasing flow rates. Stimulation of the postganglionic sympathetic fibers from the stellate ganglion caused a rise in the intrapulmonary vascular and extra-pulmonary venous resistances, which was more marked at high flow rates. Stimulation of the cervical vagosympathetic trunk caused either a rise or a fall in both intrapulmonary vascular and extrapulmonary venous resistances. Epinephrine, norepinephrine, acetylcholine, 5-hydroxytryptamine, histamine, angiotensin, and adenosine triphosphate usually caused a rise in both the intrapulmonary vascular and extra-pulmonary venous resistances. Denervation of the lung seemed to accentuate the effect of the drugs on the pulmonary vein.

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