JPET

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Long, J. P.
Right arrow Articles by Eckstein, J. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Long, J. P.
Right arrow Articles by Eckstein, J. W.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Hazardous Substances DB
*NEOSTIGMINE
Journal of Pharmacology And Experimental Therapeutics, Vol. 133, Issue 2, 216-222, 1961
Copyright © 1961 by American Society for Pharmacology and Experimental Therapeutics

GANGLIONIC ACTIONS OF NEOSTIGMINE METHYLSULFATE

J. P. Long 1 and J. W. Eckstein 1

1 Department of Pharmacology and Department of Internal Medicine, College of Medicine, State University of Iowa, Iowa City, Iowa

Intravenous administration of neostigmine methylsulfate produced a pressor response in anesthetized animals following the administration of various competitive ganglionic blocking agents. This pressor response was not observed following the noncompetitive ganglionic blocking agent tetramethylammonium bromide.

The pressor response was antagonized by hemicholinium, bretylium, reserpine and various adrenolytic and anticholinergic agents.

When neostigmine was administered into the constantly perfused forelimb by arterial injection there was no vasoconstriction. Neostigmine administered intravenously produced constriction when the cervical chain had not been sectioned.

Neostigmine did not liberate pressor amines during perfusion of the isolated kidney amid adrenal gland.

Neostigmine given in the presence of ganglionic blockade produced myocardial and peripheral vascular responses similar to those seen with sympathetic nerve stimulation or administration of catecholamines.

The data from these experiments indicate that neostigmine acts at sympathetic ganglia.

Submitted on February 16, 1961






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1961 by the American Society for Pharmacology and Experimental Therapeutics.