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Journal of Pharmacology And Experimental Therapeutics, Vol. 133, Issue 2, 192-201, 1961
Copyright © 1961 by American Society for Pharmacology and Experimental Therapeutics

AN EVALUATION OF ADRENERGIC BLOCKADE OF THE MAMMALIAN HEART

Neil C. Moran 1 and Marjorie E. Perkins 1

1 Department of Pharmacology, Division of Basic Health Sciences, Emory University, Atlanta, Georgia

The influence of the alpha adrenergic blocking drugs phenoxybenzamine, phentolamine, chlorpromazine and dihydroergotamine on the positive inotropic effect of adrenergic stimuli in mammalian hearts was re-evaluated. No evidence was found to support the contention that these drugs possess selective cardiac adrenergic blocking properties.

Submitted on January 31, 1961






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Copyright © 1961 by the American Society for Pharmacology and Experimental Therapeutics.