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Journal of Pharmacology And Experimental Therapeutics, Vol. 132, Issue 2, 251-257, 1961
Copyright © 1961 by American Society for Pharmacology and Experimental Therapeutics

ENHANCEMENT OF AMPHETAMINE STIMULATION AND PROLONGATION OF BARBITURATE DEPRESSION BY A SUBSTITUTED PYRID[3,4-b]INDOLE DERIVATIVE

Louis S. Harris 1 and Frederick C. Uhle 2

1 Sterling-Winthrop Research Institute, Rensselaer, New York
2 Department of Pharmacology, Harvard Medical School, Boston, Massachusetts

3,5-Dicarbomethoxy-1,2,3,4-tetrahydro-2-methyl-9H-pyrid[3,4-b]indole possesses the capacity of provoking marked enhancement of the stimulatory influence of amphetamine on "spontaneous activity" in mice. On the other hand, it is capable of prolonging the central depression induced by ethanol, by pentobarbital and by hexobarbital.

With the isolated virgin rat uterus in estrus the compound behaves as a weak, nonspecific antagonist to 5-hydroxytryptamine. With the isolated frog sartorius muscle it exhibits pronounced anti-veratrinic properties.

Submitted on October 3, 1960






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Copyright © 1961 by the American Society for Pharmacology and Experimental Therapeutics.