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Journal of Pharmacology And Experimental Therapeutics, Vol. 132, Issue 2, 245-250, 1961
Copyright © 1961 by American Society for Pharmacology and Experimental Therapeutics

ANALYSIS OF THE SPINAL EXCITATORY ACTION OF PENTYLENETETRAZOL

Jorge Lewin 1 and Don W. Esplin 2

1 Department of Pharmacology, Catholic University of Chile, Santiago, Chile
2 Department of Pharmacology, University of Utah, College of Medicine, Salt Lake City, Utah

Pentylenetetrazol (Metrazol) was studied in 39 spinal cord experiments in unanesthetized cats. The doses employed (20 to 60 mg/kg) generally reduced the monosynaptic spike and increased polysynaptic activity.

The effects of Metrazol on synaptic recovery in the 2N pathway are complex: recovery appears to be enhanced at stimulus intervals less than 200 milliseconds and decreased at longer intervals. Recovery processes of the motoneuron are not directly affected by the drug. The results suggest that Metrazol enhances synaptic recovery by a presynaptic action but that this effect is modified by stimulation of interneuronal systems which are primarily inhibitory.

Metrazol was found to enhance recurrent inhibition. The results suggest that the drug increases the intensity and duration of evoked Renshaw cell discharges. The effect of Metrazol to stimulate inhibitory systems is discussed in relation to the cerebral versus the spinal locus of its convulsant action.

All the effects of Metrazol were antagonized by appropriate doses of trimethadione.

Submitted on October 6, 1960




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S. Irwin and A. Benuazizi
Pentylenetetrazol Enhances Memory Function
Science, April 1, 1966; 152(3718): 100 - 102.
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