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1 Department of Pharmacology, College of Medicine, State University of New York Downstate Medical Center, Brooklyn, New York
The splanchnic nerves of dogs have been stimulated and the effect of stimulation frequency on the composition of the adrenal medullary discharge has been investigated. Maximum catecholamine output was obtained in the frequency range of 15 to 20 pulses per second.
Stimulation in the frequency range of 1 to 10 pulses per second discharged an effluent containing 65 ± 2% epinephrine. A shift favoring the release of epinephrine was noted at a frequency of 20 pulses per second. The values obtained were 84 ± 2% epinephrine.
Locally induced "thermal blockade" produced significant variations in the percentage of epinephrine released at a given frequency. Partial severance of the splanchnic nerve also caused a shift in the norepinephrine-epinephrine ratio.
The epinephrine component of the medullary secretion was most labile and decreased to a greater degree than norepinephrine in the majority of experiments involving neural blockade. These data support the concept of a selective release of adrenal medullary hormones.
Submitted on October 11, 1960
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