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Journal of Pharmacology And Experimental Therapeutics, Vol. 132, Issue 2, 212-217, 1961
Copyright © 1961 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF ANTICOAGULANTS ON THE RESPIRATION OF RAT LIVER SLICES

Walter D. Wosilait 1

1 Department of Pharmacology, State University of New York, Downstate Medical Center, Brooklyn, New York

Agents possessing anticoagulant activity, such as Dicumarol, Tromexan, warfarin, Sintrom, cumachlor, phenindione, and salicylate, which inhibited purified vitamin K1 reductase were found to depress the respiration of rat liver slices. Dicumarol was found to be the most potent, salicylate the least potent, while the others were intermediate. A similar relative order of potency was obtained for the series of anticoagulants with respect to inhibition of respiration and for the inhibition of vitamin K1 reductase.

Submitted on November 1, 1960






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Copyright © 1961 by the American Society for Pharmacology and Experimental Therapeutics.