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Journal of Pharmacology And Experimental Therapeutics, Vol. 132, Issue 2, 176-182, 1961
Copyright © 1961 by American Society for Pharmacology and Experimental Therapeutics

COMPARATIVE ACTION OF RESERPINE, TETRABENAZINE AND CHLORPROMAZINE ON CENTRAL PARASYMPATHETIC ACTIVITY: EFFECTS ON PUPILLARY SIZE AND LACRIMATION IN RABBIT AND ON SALIVATION IN DOG

D. F. Bogdanski 1, F. Sulser 1, and B. B. Brodie 1

1 Laboratory of Chemical Pharmacology, National Heart Institute, National Institutes of Health, Bethesda, Maryland

Studies of certain autonomic responses of reserpine and tetrabenazine show that miosis, salivation and lacrimation are caused by stimulation of the parasympathetic component of the central autonomic nervous system. These compounds also induce an enhanced light reflex which is responsible for the active closure of eyelids and for the sustained miosis in the light. In contrast chlorpromazine does not increase parasympathetic tone nor does it enhance the light reflex.

Submitted on September 26, 1960






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