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Journal of Pharmacology And Experimental Therapeutics, Vol. 132, Issue 2, 171-175, 1961
Copyright © 1961 by American Society for Pharmacology and Experimental Therapeutics

PHARMACOLOGY OF SENECIOYLCHOLINE

Antonio A. Sekul 1 and William C. Holland 1

1 Department of Pharmacology, University Medical Center, Jackson, Mississippi

Senecioylcholine (beta,beta-dimethylacrylylcholine, SCh) was synthesized from choline bromide and senecioyl chloride.

Senecioylcholine was found to be a ganglion stimulant. A number of its actions are described: 1. SCh produced a pressor response in the absence of atropine. This effect was partially blocked by adrenalectomy and almost completely abolished by ganglionic blockade. 2. The pressor response to SCh was reversed by adrenergic blockade. 3. SCh produced a contraction of the nictitating membrane. This action was antagonized by ganglionic blockade. 4. SCh produced contractions of the isolated frog rectus abdominis.

The results are discussed in terms of known structure-activity relationships.

Submitted on October 12, 1960






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