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Journal of Pharmacology And Experimental Therapeutics, Vol. 132, Issue 1, 19-22, 1961
Copyright © 1961 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF GAMMA-AMINOBUTYRIC ACID ON SYNAPTIC TRANSMISSION IN AUTONOMIC GANGLIA

Richard J. Matthews 1 and Barbara J. Roberts 1

1 Pharmacology Department, The Upjohn Company, Kalamazoo, Michigan

Gamma-aminobutyric acid (GABA) has been shown to have weak depressant activity on synaptic transmission in the inferior mesenteric ganglion of the decerebrate cat.

High doses (100 µg/kg) administered intra arterially were necessary to elicit a depression.

The sensitivity of the preparations varied widely and tachyphylaxis was observed in some experiments.

No effect could be obtained in the superior cervical ganglion.

Submitted on September 17, 1960






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Copyright © 1961 by the American Society for Pharmacology and Experimental Therapeutics.