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Journal of Pharmacology And Experimental Therapeutics, Vol. 132, Issue 1, 126-130, 1961
Copyright © 1961 by American Society for Pharmacology and Experimental Therapeutics

EFFECT OF STRESS AND TRANQUILIZATION ON PLASMA FREE FATTY ACID LEVELS IN THE RAT

Samuel Mallov 1 and Peter N. Witt 1

1 Department of Pharmacology, State University of New York, Upstate Medical Center, Syracuse, New York

Female albino rats were subjected to an anxiety provoking stress induced by irregular unavoidable electric shocking for periods of frac12 to 7 hours. Plasma free fatty acid (FFA) concentrations rose to levels significantly above normal, the longer the period of stress, the greater being the rise. Rats receiving the tranquilizer chlorpromazine or meprobamate, and subjected to the stress for 4 hours, manifested either smaller or no rises in plasma FFA, depending upon the dose and time of drug administration, in contrast to control animals not receiving a drug. It is concluded that it is possible to inhibit the FFA response to stress by affecting the central nervous system with tranquilizing drugs as well as by inhibiting peripheral autonomic stimulation of fatty depots.

Submitted on September 6, 1960




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Copyright © 1961 by the American Society for Pharmacology and Experimental Therapeutics.