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Journal of Pharmacology And Experimental Therapeutics, Vol. 131, Issue 3, 366-372, 1961
Copyright © 1961 by American Society for Pharmacology and Experimental Therapeutics

CLOSE SIMILARITY AND MINOR DIFFERENCES BETWEEN BRADYKININ AND KALLIDIN

C. G. Van Arman 1 and L. M. Miller 2

1 Miles Laboratories, Inc., Elkhart, Indiana
2 G. D. Searle & Co., Chicago, Illinois

Attempts to distinguish between bradykinin and kallidin in assays using isolated organs and whole animals were unsuccessful. Electrophoresis likewise did not distinguish them. Chromatograms of bradykinin made by trypsin on bovine serum were not different from those of kallidin. However, bradykinin made by venom of Agkistrodon contortrix acting on dog serum definitely had two different components, and there is a suggestion that kallidin from dog serum might have two components which behave nearly alike.

Submitted on August 18, 1960






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Copyright © 1961 by the American Society for Pharmacology and Experimental Therapeutics.