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Journal of Pharmacology And Experimental Therapeutics, Vol. 131, Issue 1, 44-48, 1961
Copyright © 1961 by American Society for Pharmacology and Experimental Therapeutics

THE EFFECT OF 5-HYDROXYTRYPTAMINE (SEROTONIN) ON RENAL HEMODYNAMICS, WATER AND ELECTROLYTE EXCRETION

J. Maxwell Little 1, Emily A. Angell 1, Ward Huffman 1, and William Brooks 1

1 Department of Physiology and Pharmacology, The Bowman Gray School of Medicine of Wake Forest College, Winston-Salem, N. C.

The intravenous infusion in dogs of 3.0 µg/kg/min serotonin was accompanied by a significant decrease in the renal excretion rates of sodium, chloride and potassium ions. There was no significant change in GFR, RPF, urine flow or tubular loads of ions. There was a significant increase in sodium ion reabsorption. With 1.5 µg/kg/ min serotonin infusion, only sodium ion excretion was significantly decreased. These results are interpreted as indicating a specific effect of serotonin on electrolyte reabsorption by the renal tubule in the dog.

Submitted on May 17, 1960






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