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Journal of Pharmacology And Experimental Therapeutics, Vol. 130, Issue 4, 469-473, 1960
Copyright © 1960 by American Society for Pharmacology and Experimental Therapeutics

THE IN VITRO ACTIONS OF STEROIDS ON SMOOTH MUSCLE

Allan D. Bass 1 and James A. Setliff 1

1 Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee

Drug-induced contractions in isolated intestinal preparations of the guinea pig, mouse, rat, rabbit and dog were inhibited by a number of active steroids. Steroids with adrenocortical, estrogenic, androgenic and progestational activity were all active in this system.

Uterine and bronchial smooth muscle also showed a sensitivity to steroid action. Histamine-induced ileal contractions are less sensitive to inhibition by steroids than are contractions induced by other drugs studied.

Submitted on April 27, 1960




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