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Journal of Pharmacology And Experimental Therapeutics, Vol. 130, Issue 4, 444-449, 1960
Copyright © 1960 by American Society for Pharmacology and Experimental Therapeutics

CARDIOVASCULAR AND BEHAVIORAL EFFECTS OF SEROTONIN AND RELATED SUBSTANCES IN DOGS WITHOUT AND WITH RESERPINE PREMEDICATION

Georg E. Cronheim 1 and James T. Gourzis 2

1 Research Division, Riker Laboratories, Northridge, California
2 Department of Pharmacology, University of Manitoba, Winnipeg 3, Canada

Slow intravenous infusions of serotonin produced in dogs, premedicated with reserpine, very marked hypotension and bradycardia as well as characteristic depression. Without reserpine premedication, serotonin had no effect.

Similar results were obtained by infusion of 5-hydroxytryptophane and .1-benzyl-2,5-di-methylserotonin.

Rapid intravenous injection of 5-hydroxytryptophane caused a characteristic central stimulation in normal dogs and severe depression in dogs pretreated with reserpine.

The implications of these observations are discussed.

Submitted on May 13, 1960






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