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Journal of Pharmacology And Experimental Therapeutics, Vol. 130, Issue 4, 427-430, 1960
Copyright © 1960 by American Society for Pharmacology and Experimental Therapeutics

EMETIC EFFECT OF INTRAVENTRICULAR APOMORPHINE AFTER ULTRASONIC DECEREBRATION IN THE CAT

H. L. Borison 1, R. Rosenstein 1, and W. G. Clark 1

1 Department of Pharmacology, University of Utah College of Medicine, Salt Lake City, Utah

Two lines of evidence have been presented which support the hypothesis of a direct emetic action of intraventricular apomorphine at the medullary emetic chemoreceptor trigger zone in the cat. The emetic dose concentration-volume relationship of apomorphine injected into the lateral cerebral ventricle revealed that the drug solution must be given in a volume sufficient to reach the fourth ventricle in order consistently to evoke vomiting at low concentrations. Emesis was elicited with intraventricular apomorphine after ultrasonic midbrain transection, but only in those cats in which the aqueduct of Sylvius remained patent.

Submitted on May 9, 1960






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