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Journal of Pharmacology And Experimental Therapeutics, Vol. 130, Issue 4, 367-369, 1960
Copyright © 1960 by American Society for Pharmacology and Experimental Therapeutics

INCREASED RATE OF METABOLISM OF EPINEPHRINE AND NOREPINEPHRINE BY SYMPATHOMIMETIC AMINES

Julius Axelrod 1 and Robert Tomchick 1

1 Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland

Epinephrine disappears from the whole mouse more rapidly than norepinephrine.

The sympathomimetic amines tyramine, phenylethylamine, ephedrine, d-amphetamine, phenylaminobutane and Paredrine (p-hydroxy-amphetamine) markedly increase the rate of disappearance of epinephrine and norepinephrine in the whole mouse.

Submitted on March 26, 1960




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Copyright © 1960 by the American Society for Pharmacology and Experimental Therapeutics.