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Journal of Pharmacology And Experimental Therapeutics, Vol. 130, Issue 3, 364-366, 1960
Copyright © 1960 by American Society for Pharmacology and Experimental Therapeutics

POTENCY OF THIOPENTAL PLUS beta,beta-ETHYLMETHYLGLUTARIMIDE

J. Weldon Bellville 1, Terence Murphy 2, and William S. Howland 2

1 Stanford Medical Center, Palo Alto, California
2 Department of Anesthesiology, Memorial Hospital and Section of Experimental Anesthesia, Division of Experimental Surgery, Sloan-Kettering Institute, New York City

The potency ratio of thiopental and a 3:1 mixture of thiopental + beta,beta-ethylmethylglutarimide has been determined in seven dogs by a servo-controlled, cross-over experiment employing the electroencephalogram as an index of drug action. Thiopental was found to be 1.51 times as potent as thiopental plus beta,beta-ethylmethylglutarimide. The upper and lower 95% confidence limits were 2.3 and 1.1, respectively.

Submitted on February 25, 1960






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