PHARMACOLOGICAL PROPERTIES OF PIPERIDINOETHYL-3-METHYLFLAVONE-8-CARBOXYLATE HYDROCHLORIDE, A SMOOTH-MUSCLE RELAXANT

¹ Research Department, Recordati Laboratorio Farmacologico S.p.A., Milan, Italy

The pharmacological properties of piperidinoethyl-3-methyiflavone-8-carboxylate hydrochloride (Rec 7-0040), a new papaverine-like smooth-muscle relaxant, are described. The new drug has a lower acute toxicity than papaverine and, on many preparations, a higher antispastic activity, whereas the movements of the intestine seem less affected by Rec 7-0040 than by papaverine. The smooth-muscle-relaxing activity of the new drug can be demonstrated also in vivo on the intestinal and bronchial musculature. The dilator activity on the peripheral vascular bed is about 10 to 20 times lower than that of papaverine. In contradistinction to papaverine, Rec 7-0040 shows also a marked analgesic and local anesthetic action. The new compound does not seem to interfere with the autonomic nervous system.