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Journal of Pharmacology And Experimental Therapeutics, Vol. 130, Issue 3, 340-345, 1960
Copyright © 1960 by American Society for Pharmacology and Experimental Therapeutics

SPECIFIC BLOCKADE OF THE ADRENAL MEDULLA

Robert W. Gardier 1, Benedict E. Abreu 2, Alice B. Richards 2, and Herman C. Herrlich 3

1 Departments of Pharmacology and Anesthesiology, Indiana University School of Medicine, Indianapolis, Indiana
2 Research Division, Pitman-Moore Company, Indianapolis, Indiana
3 Department of Medicine, University of Vermont, Burlington, Vermont

N,N-diisopropyl- N'-isoamyl-N'-diethylaminoethylurea (P-286) reverses the pressor response to acetyicholine in the atropinized dog. This reversal is due to selective blockade of the action of acetyicholine in the adrenal medulla.

P-286 possesses a transient vasodepressor action per se, has weak ganglionic blocking action, and is not an adrenergic blocking agent.

Submitted on March 24, 1960




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