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Journal of Pharmacology And Experimental Therapeutics, Vol. 130, Issue 3, 262-267, 1960
Copyright © 1960 by American Society for Pharmacology and Experimental Therapeutics

THE ENZYMATIC FORMATION OF SULFOXIDES: THE OXIDATION OF CHLORPROMAZINE AND 4,4'-DIAMINODIPHENYL SULFIDE BY GUINEA PIG LIVER MICROSOMES

James R. Gillette 1 and Jerome J. Kamm 1

1 Laboratory of Chemical Pharmacology, National Heart Institute, National Institutes of Health, Department of Health, Education, and Welfare, Bethesda, Maryland

Chlorpromazine and 4,4'-diaminodiphenyl sulfide are oxidized to their sulfoxide derivatives by an enzyme system in guinea pig liver homogenates. The enzyme system is localized in the microsomes, and requires reduced triphosphopyridine nucleotide and oxygen. The enzyme system probably is not a peroxidase.

Submitted on March 2, 1960






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