JPET xPharm- The Comprehensive Pharmacology Reference

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wylie, D. W.
Right arrow Articles by Arnold, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wylie, D. W.
Right arrow Articles by Arnold, A.
Journal of Pharmacology And Experimental Therapeutics, Vol. 130, Issue 3, 239-244, 1960
Copyright © 1960 by American Society for Pharmacology and Experimental Therapeutics

AUGMENTATION OF PHARMACOLOGICAL PROPERTIES OF CATECHOLAMINES BY O-METHYL TRANSFERASE INHIBITORS

D. W. Wylie 1, S. Archer 1, and A. Arnold 1

1 Pharmacology Section and Organic Chemistry Division, Sterling-Winthrop Research Institute, Rensselaer, New York

A series of polyphenols have been found to reduce methylation of epinephrine and norepinephrine by O-methyl transferase in vitro, probably by acting as competitive substrates.

These substances augmented the toxicity of intravenous epinephrine in the rat, the augmented toxicity being adrenergic in nature and probably due to an increase in the life-span of epinephrine. The effects with norepinephrine were less pronounced.

The inhibitors prolonged the duration of the pressor effects of epinephrine in the spinal cat, but were less active in prolonging the effect of norepinephrine.

Pyrogallol, when given repeatedly, caused a rise in blood pressure, but this was soon followed by what appeared to be tachyphylaxis.

Pyrogallol prolonged the duration of action of endogenously released catecholamines at the nictitating membrane.

Possible explanations for the difference between epinephrine and norepinephrine are discussed.

Submitted on February 27, 1960




This article has been cited by other articles:


Home page
 ScienceHome page
J. Axelrod
Noradrenaline: Fate and Control of Its Biosynthesis
Science, August 13, 1971; 173(3997): 598 - 606.
[PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1960 by the American Society for Pharmacology and Experimental Therapeutics.