JPET Introducing ALZET?ew Model 2006 Pump

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Journal of Pharmacology And Experimental Therapeutics, Vol. 130, Issue 2, 218-221, 1960
Copyright © 1960 by American Society for Pharmacology and Experimental Therapeutics

STUDIES OF ANALGESIC DRUGS: IV. DISSOCIATION OF ANALGESIC, RESPIRATORY AND EMETIC EFFECTS

Arthur S. Keats 1, Jane Telford 1, and Yoshio Kurosu 1

1 Division of Anesthesiology, Baylor University College of Medicine, and Jefferson Davis Hospital, Houston, Texas

The analgesic, respiratory and subjective effects of 4-acetoxy-3-methyl-1-(phenylethyl)-4-0-tolylpiperidine hyrochloride have been studied in man. This compound has demonstrated a remarkable quantitative dissociation in the analgesic, respiratory and emetic activities considered to be obligatory side actions of potent analgesics. In doses which produce analgesia

equivalent to morphine, this compound produced severe respiratory depression, minimal nausea and no vomiting. The significance of the demonstration of this dissociation has been discussed.

Submitted on January 28, 1960






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