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Journal of Pharmacology And Experimental Therapeutics, Vol. 130, Issue 2, 204-211, 1960
Copyright © 1960 by American Society for Pharmacology and Experimental Therapeutics

QUANTITATIVE ELECTROENCEPHALOGRAPHIC STUDIES ON THE EFFECTS OF MORPHINE AND NALORPHINE ON RABBIT BRAIN

Jorge Aldunate 1 and Leonide Goldstein 2

1 Instituto de Farmacologia, Universidad de Chile, Santiago, Chile
2 Division of Basic Health Sciences, Department of Pharmacology, Emory University, Atlanta 22, Georgia

Quantitative electroencephalographic studies have been done on the effects of morphine and nalorphine on brain electrogenesis in rabbits.

It has been found that the curves relating log-dose/effect are not the same for the effects of these drugs.

The blocking action of nalorphine on morphine revealed an apparent all-or-none threshold of action and a proportionally longer duration of action for small doses of nalorphine than for large doses.

Submitted on February 15, 1960






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