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Journal of Pharmacology And Experimental Therapeutics, Vol. 130, Issue 2, 138-143, 1960
Copyright © 1960 by American Society for Pharmacology and Experimental Therapeutics

A STUDY OF THE CENTRAL DEPRESSANT ACTION OF PENTOBARBITAL, PHENOBARBITAL AND DIETHYL ETHER IN RELATIONSHIP TO INCREASES IN BRAIN 5-HYDROXYTRYPTAMINE

Edmund G. Anderson 1 and Desmond D. Bonnycastle 1

1 Department of Pharmacology, Seton Hall College of Medicine and Dentistry, Jersey City, New Jersey

The relationship between the rise in brain 5-HT and the central nervous system (CNS) depressant action of pentobarbital, phenobarbital and diethyl ether has been investigated.

With both pentobarbital and phenobarbital a close correlation was observed between the elevation in brain 5-HT and the depth of CNS depression observed. With pentobarbital depression of the CNS was found to immediately precede the rise in brain 5-HT, and with diethyl ether the CNS depression was observed to occur long before the rise in brain 5-HT. It is thus concluded that the CNS depressant activity of these compounds cannot be mediated by a central 5-HT mechanism. The possibility of CNS depression causing a rise in brain 5-HT is discussed.

Submitted on January 21, 1960






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