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Journal of Pharmacology And Experimental Therapeutics, Vol. 13, Issue 3, 167-181, 1919
Copyright © 1919 by American Society for Pharmacology and Experimental Therapeutics

THE ACTION OF DRUGS ON THE OUTPUT OF EPINEPHRIN FROM THE ADRENALS II. CONCENTRATED SALT SOLUTIONS (SODIUM CARBONATE) INJECTED INTO THE CIRCULATION

G. N. STEWART 1 and J. M. ROGOFF 1

1 From the H. K. Cushing Laboratory of Experimental Medicine, Western Reserve University

1. Intravascular injection of small volumes of concentrated salt solutions (sodium carbonate) causes a temporary increase in the rate of liberation of epinephrin from the adrenals.

2. This increase is presumably due to stimulation of the nervous mechanism which governs the epinephrin output since it is accompanied by symptoms of a general excitation of the bulbo-spinal centers, and is not obtained, or only in a minor degree, when even larger quantities of the carbonate are injected in more dilute form.

3. In experiments on epinephrin output, it is not advisable to use concentrated solutions of salts in tubes connecting an artery with a mercurial manometer.

Submitted on March 31, 1919






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Copyright © 1919 by the American Society for Pharmacology and Experimental Therapeutics.