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Journal of Pharmacology And Experimental Therapeutics, Vol. 129, Issue 4, 388-393, 1960
Copyright © 1960 by American Society for Pharmacology and Experimental Therapeutics

RENAL TUBULAR TRANSPORT RELATIONSHIPS BETWEEN N1-METHYLNICOTINAMIDE (NMN), MECAMYLAMINE, QUININE, QUINIDINE AND QUINACRINE IN THE AVIAN KIDNEY

R. L. Volle 1, R. E. Green 2, and Lawrence Peters 2

1 Department of Pharmacology, School of Medicine, University of Pennsylvania, Philadelphia
2 Department of Pharmacology, University of Kansas Medical Center, Kansas City, Kansas

The renal tubular excretion of N1-methylnicotinamide (NMN) was inhibited by mecamylamine, quinine, quinidine and quinacrine when the inhibitors and NMN were infused simultaneously into the portal circulation of one kidney in the chicken.

Quinine also inhibited the tubular excretion of tetraethylammonium.

The rates of excretion of quinine and mecamylamine themselves were of a low order of magnitude even though the urine was acid.

The possibility of a relationship between the tubular excretion of mecamylamine and certain other amines in the mammalian kidney, which has been regarded as a passive non-ionic diffusion process, and the tubular excretion of NMN, which is believed to be based on active transport, is discussed.

Submitted on December 3, 1959




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[Abstract] [Full Text]


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