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Journal of Pharmacology And Experimental Therapeutics, Vol. 129, Issue 4, 373-376, 1960
Copyright © 1960 by American Society for Pharmacology and Experimental Therapeutics

THE ROLE OF ALCOHOL DEHYDROGENASE IN THE METABOLISM OF CHLORAL HYDRATE

Paul J. Friedman 1 and Jack R. Cooper 1

1 Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut

Evidence is offered that the principal mediator of the reduction of chloral hydrate to trichloroethanol in the body is alcohol dehydrogenase. The enzyme responsible for the reduction of chloral hydrate is shown to be DPNH-dependent, and, like that involved in the reduction of acetaldehyde, is found in the soluble portion of the cell, and is affected in the same way by purification procedures and by certain inhibitors of enzymic activity.

Submitted on December 4, 1959






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