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Journal of Pharmacology And Experimental Therapeutics, Vol. 129, Issue 2, 132-138, 1960
Copyright © 1960 by American Society for Pharmacology and Experimental Therapeutics

OBSERVATIONS ON THE DRUG-INDUCED SYNTHESIS OF D-GLUCURONIC, L-GULONIC AND L-ASCORBIC ACIDS IN RATS

J. J. Burns 1, A. H. Conney 1, Peter G. Dayton 1, Carole Evans 1, G. R. Martin 1, and Dolores Taller 1

1 Laboratory of Chemical Pharmacology, National Heart Institute, National Institutes of Health, Bethesda, Maryland, and New York University Research Service, Goldwater Memorial Hospital, Welfare Island, New York

Various drugs possessing completely unrelated chemical and pharmacological properties stimulate the biosynthesis of L-ascorbic acid in rats. Among these compounds are included barbital, Chloretone, meprobamate, phenylbutazone, chlorcyclizine, diphenhydramine, orphenadrine, 3-methylcholanthrene and 3,4-benzpyrene. The ability of barbital and Chloretone to enhance the synthesis of free D-glucuronic acid and L-gulonic acid was also observed. The mechanism by which drugs stimulate ascorbic acid biosynthesis is not known but renal factors and drug glucuronide formation are not involved. The possibility was considered that this drug effect on ascorbic acid formation results from increased metabolism of glucose through the glucuronic acid pathway.

Submitted on October 22, 1959




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