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Journal of Pharmacology And Experimental Therapeutics, Vol. 129, Issue 2, 123-127, 1960
Copyright © 1960 by American Society for Pharmacology and Experimental Therapeutics

AN EFFECT OF CARDIAC GLYCOSIDES ON OXIDATIVE PHOSPHORYLATION BY HEART MITOCHONDRIA

Kwang Soo Lee 1, Arnold Schwartz 1, and Roselle Burstein 1

1 Department of Pharmacology, College of Medicine of the State University of New York Downstate Medical Center, Brooklyn, New York

The P:O ratios, oxygen consumption in ADP- or IP-deficient media, and ATPase activity of heart mitochondria isolated from digitoxin or ouabain-poisoned guinea pig were studied.

These mitochondria were found to utilize more oxygen in an ADP- or IP-deficient medium than the control mitochondria.

The respiratory response of these mitochondria to the addition of hexokinase and glucose to the ADP-deficient medium was less than that of the controls. The P:O ratio and ATPase activity were unchanged when compared to the controls.

Submitted on November 9, 1959






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