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Journal of Pharmacology And Experimental Therapeutics, Vol. 129, Issue 1, 94-100, 1960
Copyright © 1960 by American Society for Pharmacology and Experimental Therapeutics

ENZYMATIC PATHWAY FOR THE FORMATION OF COTININE, A MAJOR METABOLITE OF NICOTINE IN RABBIT LIVER

H. B. Hucker 1, J. R. Gillette 1, and B. B. Brodie 1

1 Laboratory Of Chemical Pharmacology, National Heart Institute, National Institutes Of Health, Bethesda, Maryland

A main reaction of nicotine metabolism in rabbit appears to be hydroxylation in the alpha position of the pyrrolidine ring to form a hydroxynicotine. This oxidation occurs in liver microsomes and requires TPNH and O2; the product has the properties of a cyclized amino aldehyde. The hydroxynicotine then undergoes oxidation to cotinine, a reaction that may be catalyzed by an aldehyde oxidase.

Submitted on October 19, 1959




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Copyright © 1960 by the American Society for Pharmacology and Experimental Therapeutics.