A STUDY OF THE DIURETIC EFFECT OF TRIAMCINOLONE IN THE DOG

¹ Experimental Therapeutics Research, Lederle Laboratories Division, American Cyanamid Company, Pearl River, New York

Studies in fasted and nonhydrated female dogs after single oral or intravenous doses (8 to 250 µg/kg) have shown: a) an increase in the rate of excretion of urinary sodium and chloride and in urine flow; b) a slight increase in the rate of excretion of urinary potassium; c) a maximum rate of excretion not attained until approximately 4 hours after dosage; d) a maximum total daily urinary sodium excretion about 5-fold the control value that can be produced with a dose as low as 60 µg/kg; e) no hyperglycemic effect at these doses; f) similar responses with either route of administration.

After repeated daily oral administration of triamcinolone (10 to 270 µg/kg/day) to fed and hydrated (water ad libitum) female dogs the following observations were made: a) there was an increase in the daily urinary excretion of chloride (chloruresis) and sodium (natriuresis); b) the weekly 3-fold increase in dose did not always result in a greater chloruresis and natriuresis; c) during the 18-day period of no drug ("recovery" period) the urinary excretion of chloride and sodium was below normal values for the first 3 to 5 days and then returned to levels similar to the control period; d) there was also some increase in potassium excretion (total mEq/day) though this effect was less than for sodium on chloride; e) parallel increases in daily water intake and urine volume were recorded; f) plasma electrolytes (HCO₃^-, Cl^-, Na⁺ and K⁺) and plasma glucose varied within normal values; g) food intake was normal and constant throughout the test; however, slight losses in body weight, within 10% of control period weights, were recorded.