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Journal of Pharmacology And Experimental Therapeutics, Vol. 129, Issue 1, 42-48, 1960
Copyright © 1960 by American Society for Pharmacology and Experimental Therapeutics

POTASSIUM BALANCE OF THE DOG HEART: EFFECTS OF INCREASING HEART RATE AND OF PENTOBARBITAL AND DIHYDRO-OUABAIN

T. Brown 1, G. Grupp 1, and G. H. Acheson 1

1 Department of Pharmacology, University of Cincinnati, College of Medicine, Cincinnati, Ohio

In dogs, cardiac potassium balance was not altered by elevation of heart rate in 27 heartlungs and 4 open-chest preparations, under pentobarbital anesthesia or after cyclopropane anesthesia.

Additional pentobarbital (45 to 180 mg) caused cardiac failure but did not affect cardiac potassium balance. Acceleration of heart rate now caused loss of potassium from the heart.

Dihydro-ouabain (300 µg) reversed the failure produced by pentobarbital and caused potassium loss from the heart beating at normal rate. Acceleratioll of heart rate now caused the same potassium loss seen with pentobarbital failure.

Submitted on October 26, 1959






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