JPET xPharm- The Comprehensive Pharmacology Reference

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bellville, J. W.
Right arrow Articles by Howland, W. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bellville, J. W.
Right arrow Articles by Howland, W. S.
Journal of Pharmacology And Experimental Therapeutics, Vol. 129, Issue 1, 108-114, 1960
Copyright © 1960 by American Society for Pharmacology and Experimental Therapeutics

THE RELATIVE POTENCIES OF METHOHEXITAL AND THIOPENTAL

J. Weldon Bellville 1, Peter J. Fennel 1, Terence Murphy 1, and William S. Howland 1

1 Department of Anesthesiology, Memorial Hospital and Section of Experimental Anesthesia, Division of Experimental Surgery, Sloan-Kettering Institute, New York, New York

The relative potency of methohexital and thiopental has been determined in man and in dog by servo-controlled cross-over experiments.

In terms of their action in man in producing electroencephalographic changes commonly associated with deepening barbiturate anesthesia, methohexital was found to be 2.78 times as potent as thiopental. The 95% confidence limits are 3.5 and 2.2, respectively. In the cross-over experiment carried out in the four dogs, the potency of methohexital relative to thiopental (phgr) was found to be 3.07.

Submitted on June 17, 1959






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1960 by the American Society for Pharmacology and Experimental Therapeutics.