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Journal of Pharmacology And Experimental Therapeutics, Vol. 128, Issue 4, 414-418, 1960
Copyright © 1960 by American Society for Pharmacology and Experimental Therapeutics

A SEQUENTIAL PROBABILITY RATIO METHOD FOR DETECTING COMPOUNDS WITH DIURETIC ACTIVITY IN RATS

J. R. Cummings 1, J. D. Haynes 1, L. M. Lipchuck 1, and M. A. Ronsberg 1

1 Experimental Pharmacology Department, Experimental Therapeutics Research Section and Statistical Laboratory, Lederle Laboratories Division, American Cyanamid Company, Pearl River, New York

A method for detecting compounds with diuretic activity in the rat by sequential analysis is presented. Two sequential probability ratio procedures based on 0-5-hour and 0-24-hour urine volumes are described.

Of the standard diuretics which were tested, acetazolamide, amisometradine, chlorothiazide, chlormerodrin, hydrochlorothiazide, meralluride and theophylline were accepted. Urea was rejected.

The reduced amount of experimentation required by sequential testing as compared to conventional statistical testing is discussed.

Submitted on September 25, 1959






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