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Journal of Pharmacology And Experimental Therapeutics, Vol. 128, Issue 4, 392-396, 1960
Copyright © 1960 by American Society for Pharmacology and Experimental Therapeutics

ELECTROENCEPHALOGRAPHIC ANALYSIS OF THE EFFECT OF 2-DIMETHYLAMINOETHANOL, CHOLINE AND ATROPINE ON THE RABBIT BRAIN

Leonide Goldstein 1

1 Department of Pharmacology, Division of Basic Health Sciences, Emory University, Atlanta, Georgia

Quantitative electroencephalographic studies of cortical electrogenesis have been performed on waking, unrestrained rabbits.

Deanol (5 mg/kg, i.v.) produced, after a 30-minute latency period, a marked and longlasting increase of the voltage output. The EEG pattern was of hypersynchronization but the behavior of the animals was of overexcitation.

Choline (5 mg/kg, i.v.) did not exert any discernible effect but approximately doubled the latency period for the onset of action of deanol.

Atropine (1 mg/kg, i.v.) produced a transient depression of the effect of deanol.

Submitted on October 2, 1959






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