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Journal of Pharmacology And Experimental Therapeutics, Vol. 128, Issue 4, 384-391, 1960
Copyright © 1960 by American Society for Pharmacology and Experimental Therapeutics

PHARMACOLOGIC STUDIES OF A NEW ANTITUSSIVE, ALPHA (DIMETHYLAMINOETHYL)-ORTHO-CHLOROBENZHYDROL HYDROCHLORIDE (SL-501, BAYER B-186)

James Y. P. Chen 1, Hugh F. Biller 1, and Edwin G. Montgomery Jr. 1

1 Department of Pharmacology, Marquette University School of Medicine, Milwaukee, Wisconsin

The relative antitussive efficacies of alpha (dimethylaminoethyl)-ortho-chlorobenzhydrol hydrochloride (SL-501, Bayer B-186), codeine, dihydrocodeinone and several currently used nonnarcotic antitussives have been appraised by a method in which experimental cough was induced by aerosolized N sulfuric acid in unanesthetized dogs. SL-501, a new nonnarcotic antitussive, shows a potent and long-acting cough-suppressing activity in dogs. It has a relatively slower onset of maximum action than the narcotics.

SL-501 exhibits moderate local anesthetic effects and a mild antispasmodic action. It also causes some prolongation of sleeping time in pentobarbitalized mice. No analgesic, sedative-hypnotic, antihistaminic or antiemetic properties were demonstrated.

Acute and chronic toxicity studies in animals indicate that SL-501 is relatively nontoxic, and has a high therapeutic ratio.

Submitted on September 24, 1959






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Copyright © 1960 by the American Society for Pharmacology and Experimental Therapeutics.