JPET

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Waud, D. R.
Right arrow Articles by Krayer, O.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Waud, D. R.
Right arrow Articles by Krayer, O.
Journal of Pharmacology And Experimental Therapeutics, Vol. 128, Issue 4, 352-357, 1960
Copyright © 1960 by American Society for Pharmacology and Experimental Therapeutics

THE RATE-INCREASING EFFECT OF EPINEPHRINE AND NOREPINEPHRINE AND ITS MODIFICATION BY EXPERIMENTAL TIME IN THE ISOLATED HEART OF NORMAL AND RESERPINE-PRETREATED DOGS

D. R. Waud 1 and O. Krayer 1

1 Department of Pharmacology, Harvard Medical School, Boston, Massachusetts

Reserpine pretreatment of the dog in a dose sufficient to deplete endogenous cardiac catecholamines does not influence the chronotropic effects of l-epinephrine and l-norepinephrine upon the heart-lung preparation of the dog. Epinephrine and norepinephrine are indistinguishable with regard to chronotropic potencies. The chronotropic effects are reduced late in the experiment.

The decay of epinephrine-induced cardio-acceleration in the heart-lung preparation is slower than that induced by norepinephrine. No influence of reserpine pretreatment on cardiac competence was noted.

An example of a split-split-plot design in pharmacology is given.

Submitted on September 30, 1959






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1960 by the American Society for Pharmacology and Experimental Therapeutics.