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Journal of Pharmacology And Experimental Therapeutics, Vol. 128, Issue 4, 340-343, 1960
Copyright © 1960 by American Society for Pharmacology and Experimental Therapeutics

PHYSIOLOGICAL DISPOSITION AND METABOLIC FATE OF CHLORZOXAZONE (PARAFLEX) IN MAN

A. H. Conney 1 and J. J. Burns 1

1 Laboratory of Chemical Pharmacology, National Heart Institute, National Institutes of Health, Bethesda, Maryland, and the New York University Research Service, Goldwater Memorial Hospital, Welfare Island, New York, N. Y.

The muscular relaxant chlorzoxazone is well absorbed in man and is rapidly metabolized to 6-hydroxy-chlorzoxazone which is excreted in urine conjugated primarily as the glucuronide. Evidence has been presented for the metabolism of chlorzoxazone by liver enzymes in rat, rabbit, mouse and guinea pig.

Submitted on September 11, 1959




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Copyright © 1960 by the American Society for Pharmacology and Experimental Therapeutics.