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Journal of Pharmacology And Experimental Therapeutics, Vol. 128, Issue 4, 329-332, 1960
Copyright © 1960 by American Society for Pharmacology and Experimental Therapeutics

THE METABOLISM OF ACETYL DIGITOXIN IN THE RAT

J. F. Martin 1 and S. E. Wright 1

1 Department of Pharmacology and Pharmacy, University of Sydney, Sydney, Australia

Acetyl digitoxin, like digitoxin, has been shown to be excreted only slowly by rats. About 5% of the dose was present in the urine after 12 hours, and 9% in the bile after 6 hours.

The urine contained acetyl digitoxin, digitoxin, 12-hydroxy digitoxin (digoxin) and digoxin metabolite B. The bile contained acetyl digitoxin and digoxin. Metabolites of acetyl digitoxin were also detected in the blood, liver, heart and kidneys of rats.

Submitted on September 10, 1959






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Copyright © 1960 by the American Society for Pharmacology and Experimental Therapeutics.